Israel Regentis Biomaterials has developed a cartilage repair hydrogel. This hydrogel is composed of polyvinyl alcohol and a certain proportion of fibrinogen. It is a biodegradable synthetic material. After being injected into the cartilage injury site, it can be condensated into a desired shape according to the need and induced by the released fibrinogen. The cartilage cells are regenerated and naturally fuse with the surrounding tissue.
The company’s chief executive officer, Yaya Hill Taur, stated that the key to the development of this material is to keep cartilage tissue regeneration in sync with biodegradation. Some of the other materials used today are ineffective, mainly due to excessive degradation. The hydrogel they developed has strong controllability by adjusting the ratio of polyvinyl alcohol to fibrinogen. When the proportion of polyvinyl alcohol is high, the biodegradation process can be slowed down, giving cells enough time to grow and heal.
Knee cartilage is a transparent joint soft tissue that plays an important role in the lubrication, shock absorption and weight bearing of the knee joint. After the cartilage of the knee is damaged, its ability to regenerate is weak due to a lack of blood supply. It is said that the current market size of cartilage regeneration globally is 1.6 billion US dollars. There are 400,000 patients waiting for treatment in the United States and Europe. Therefore, it is necessary to develop a new method to promote cartilage regeneration.
The technology is now in the clinical trial stage and can be used for bone regeneration, spinal cord and other regenerative repairs in addition to cartilage regeneration.
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